Role of silicosis in silica associated lung cancer

Special References Synonyms and Identifiers Asbestos is the generic designation referring usually to six types of naturally occurring mineral fibers that are or have been commercially exploited.

Role of silicosis in silica associated lung cancer

This study also outlines the critical role of the inflammatory mediator LTB4 and its receptor BLT1 in promoting silica mediated lung tumor growth. Chronic silica exposure causes severe health complications eventually leading to the irreversible, debilitating disease silicosis.

Approximately 2 million U. Silicosis in the developing part of the world is of an even higher concern as it is spreading like an epidemic with more than 10 million people affected around the world as a result of rapid industrialization, massive expansion of construction industry and possibly less regulated working environments.

As of December , the most common conditions certified by the World Trade Center Health Program were rhinosinusitis, gastroesophageal reflux disease (GERD), asthma, sleep apnea, cancer, posttraumatic stress disorder, respiratory disease, chronic obstructive pulmonary disease, depression, and anxiety srmvision.com most common cancers were skin cancer and prostate cancer. When the Health and Safety Executive (HSE) visited Teesdale Architectural Stone Ltd (TASL) in September , it discovered workers were facing unacceptably high exposures to crystalline silica, a dust that can cause lung cancer, the breath-stealing disorder silicosis and other serious diseases. Role of Silicosis in Silica-associated Lung Cancer. The proposed research study attempts to clarify the role of silicosis in silica-associated lung cancer development by addressing some of the identified study design challenges. Significance. Determining if silicosis is a prerequisite for lung cancer development has important public health.

Being from Kentucky, where overall lung cancer is a major health issue, it is exciting that we may be able to develop treatments that impact people in our backyards, in addition to around the world," Bodduluri said.

Silicosis keeps progressing post-exposure because people are unable to cough up the tiny particles. Macrophages that ingest silica particles end up dying, resulting in persistent sterile inflammation and may eventually lead to lung cancer.

Though CS has been designated as a human carcinogen it also has been difficult to discern silicosis associated lung cancer because of a number of confounding factors including the fact that cigarette smoking is a common factor with workers likely to be exposed to silica.

Bodduluri and his colleagues report that in mice that develop spontaneous lung tumors, CS exposure accelerates lung tumor progression.

Role of silicosis in silica associated lung cancer

Moreover, this result also was replicated in an implantable lung cancer model. Their results highlight the importance of silica induced leukotriene B4 mediated inflammation in lung tumor promotion.

Leukotrienes are involved in regulating inflammation, especially in the lungs. Mice deficient in leukotriene B4 receptor BLT1 are significantly protected from silica induced tumor promotion, suggesting the possibility for novel treatment strategies for both silicosis and associated lung cancers.

Bodduluri and his team are world leaders in this field and this work may lead to novel therapies for lung cancer.Abundant epidemiologic and experimental evidence supports the International Agency for Research on Cancer classification of crystalline silica as a human lung .

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Role of silicosis in silica associated lung cancer

Thousands of women who have had their implants for one or two decades now are seeking medical help for mysterious symptoms which resemble arthritis, fibromyalgia, scleroderma. When the Health and Safety Executive (HSE) visited Teesdale Architectural Stone Ltd (TASL) in September , it discovered workers were facing unacceptably high exposures to crystalline silica, a dust that can cause lung cancer, the breath-stealing disorder silicosis and other serious diseases.

Glomerulonephritis, the commonest cause of end-stage renal failure in most countries, is worsened and may even be caused by exposure to chemicals present .

Physical Geology, by Brian J.

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Skinner and Stephen C. Porter A well written introductory textbook on physical geology with lots of figures. The Solid Earth - An Introduction to Global Geophysics, by C.M.R. Fowler This book has nothing to do with quartz but is about the inner workings of the planet earth, and it clearly addresses expert readers and undergraduate students of geology.

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